L-CITRULLINE

Description

NDC: 53335-006-89 (capsule), 53335-053-29 (powder)

Weight: 4 Oz

L-Citrulline is a non-essential amino acid formed in the urea cycle through the addition of carbon dioxide and ammonia to ornithine, playing a key role in detoxifying the liver from ammonia—a waste product of oxidation. It is subsequently combined with aspartic acid to form arginosuccinic acid, which is metabolized into arginine, supporting nitric oxide production and vascular health. L-Citrulline enhances energy levels, assists immune function, and is particularly beneficial for individuals with urea cycle disorders. Research highlights its efficacy in ammonia clearance and cardiovascular support (e.g., Curis et al. 2005).

L-Citrulline is especially valuable for those seeking to improve liver function, boost energy, or enhance blood vessel health under metabolic stress. Manufactured using premium pharmaceutical-grade materials in a GMP-approved facility in the USA, L-Citrulline is free of fillers, binders, or coloring agents, with no known side effects when used as directed.

Directions: Take 1-3 capsules daily or as advised by your healthcare provider. Pair with vitamins and minerals; GPD’s MVM (Multivitamin) is recommended. Powder equivalent: 1/4 level teaspoon per capsule.

Key Benefits

• Supports Liver Detoxification: Aids ammonia removal in the urea cycle.
• Enhances Vascular Health: Promotes nitric oxide via arginine conversion.
• Boosts Energy Production: Supports metabolic efficiency.

References

• Curis E, et al. (2005). “Citrulline and the gut-liver axis: Role in health and disease.” Amino Acids, NIH.
• Wu G, et al. (2009). “Arginine metabolism and nutrition in growth, health and disease.” Amino Acids, NIH.
• Schwedhelm E, et al. (2008). “Pharmacokinetic and pharmacodynamic properties of oral L-citrulline.” British Journal of Clinical Pharmacology, NIH.
• Moinard C, et al. (2008). “Citrulline: A new player in the control of nitrogen homeostasis.” Journal of Nutrition, NIH.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult a doctor or medical professional before use, especially if you have underlying health conditions or are taking other medications.

Additional Information The following points provide insight into L-Citrulline’s plasma levels and their association with various health conditions, reflecting its role in metabolism:

• Normal Range: 20-50 micromol/L (approximate clinical range).
• Conditions Associated with Low Levels:
  • Urea cycle disorders (e.g., citrullinemia, impairing ammonia detoxification)
  • Liver dysfunction (reduced citrulline synthesis)
  • Malnutrition (inadequate amino acid intake)
• Conditions Associated with High Levels:
  • Excessive supplementation (from overdosage or dietary excess)
  • Renal failure (impaired excretion of citrulline)
  • Post-exercise states (increased arginine-citrulline cycle activity)

Notes: L-Citrulline is a non-essential amino acid integral to the urea cycle, detoxifying ammonia and converting to arginine to support nitric oxide production and vascular health. It enhances energy and immune function, with specific benefits for urea cycle disorders. Low levels may indicate metabolic or liver issues, while high levels can result from supplementation or renal impairment. These associations are correlative and require further research for causal confirmation. For more technical information, please click here. Consult a doctor or medical professional before use, especially if you have underlying health conditions or are taking other medications.