L-HISTIDINE

Description

NDC: 53335-072-11 (capsule), 53335-073-29 (powder)

Weight: 4 Oz

L-Histidine is an essential amino acid, critical for various physiological processes, with its production potentially insufficient in children, though adequate in adults. Characterized by its basic nature due to an aromatic nitrogen-heterocyclic imidazole side chain, L-Histidine is metabolized into the neurotransmitter histamine and contributes to the genetic regulation of enzymes involved in its synthesis. It serves as a precursor to carnosine and anserine, supports gastric acid secretion for digestion, and influences circadian rhythms, neuronal health, and the production of red and white blood cells. Research suggests potential benefits in rheumatoid arthritis and sexual function (e.g., Kopple & Swendseid 1975).

L-Histidine is particularly beneficial for individuals seeking to support immune responses, neurological balance, or digestive health, especially during growth phases or metabolic stress. Manufactured using premium pharmaceutical-grade materials in a GMP-approved facility in the USA, L-Histidine is free of fillers, binders, or coloring agents, with no known side effects when used as directed.

Directions: Take 1-2 capsules daily or as advised by your healthcare provider. Pair with vitamins and minerals; GPD’s MVM (Multivitamin) is recommended. Powder equivalent: 1/4 level teaspoon per capsule.

Key Benefits

• Supports Immune Function: Aids red and white blood cell production.
• Enhances Neurological Health: Precursor to histamine and carnosine.
• Promotes Digestion: Supports gastric acid secretion.

References

• Kopple JD, Swendseid ME. (1975). “Evidence that histidine is an essential amino acid in normal and chronically uremic man.” Journal of Clinical Investigation, NIH.
• Boldyrev AA, et al. (2013). “Carnosine and its derivatives as antioxidants and neuroprotectors.” Amino Acids, NIH.
• Watanabe T, et al. (2002). “Histamine and the regulation of circadian rhythms.” Neuroscience Research, NIH.
• Preedy VR, et al. (2012). “Histidine metabolism and its role in health and disease.” Nutrition Research Reviews, NIH.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult a doctor or medical professional before use, especially if you have underlying health conditions or are taking other medications.

Additional Information The following points provide insight into L-Histidine’s plasma levels and their association with various health conditions, reflecting its role in metabolism:

• Normal Range: 50-100 micromol/L (approximate clinical range).
• Conditions Associated with Low Levels:
  • Growth deficiencies in children (inadequate synthesis)
  • Chronic kidney disease (increased demand or loss)
  • Histamine deficiency syndromes (e.g., impaired immune response)
• Conditions Associated with High Levels:
  • Excessive supplementation (from overdosage or dietary excess)
  • Liver dysfunction (impaired histidine metabolism)
  • Histidinemia (genetic disorder causing histidine buildup)

Notes: L-Histidine is an essential amino acid, metabolized into histamine and precursors like carnosine, supporting immune, neurological, and digestive functions. It influences circadian rhythms and blood cell production, with potential benefits in arthritis and sexual health. Low levels may indicate growth or renal issues, while high levels can result from supplementation or genetic conditions. These associations are correlative and require further research for causal confirmation. For more technical information, please click here. Consult a doctor or medical professional before use, especially if you have underlying health conditions or are taking other medications.